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Over the course of three decades writing and directing their own movies, legendary filmmaking duo Joel and Ethan Coen have established a genre of their own, generally involving underdogs and buffoons navigating hijinks and moral conundrums in distinct American landscapes. Their heroes are unextraordinary people thrown into extraordinary circumstances, their stories written with particular patois and implicit philosophical subtexts. Think Big Lebowski, Brother Where Art Thou? and Country for Old Men.

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“It’s going great. I love watching,” said Droz. “One of my goals throughout was to be able to watch myself and laugh and smile, and I am definitely accomplishing that.”. Having defined a candidate distance between two proteins in an interaction as the quotient of the number of participating proteins divided by 2, we take the smallest candidate distance among all the candidate distances between two proteins as their close distance. Because there is no order information for proteins that participate in the interactions in HPRD, the co occurrences fij and fji are treated equally. Consequently, we have pafij = pafji.