As part of the new strategy, Macy’s will rebalance its media mix partly to rely more on 15 second, local TV ads and less on 30 second national spots. Rather than confuse consumers with a billion random seeming promotions, new messaging will be organized around four annual tentpole events for spring, summer, fall and the winter holidays. They’ll be emotional in tone while highlighting an improved product mix, Lennox said..

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Replica Handbags All six population based studies could be included in the meta analysis (fig 2), which showed a significant association of white matter hyperintensities with risk of stroke (hazard ratio 3.1, 95% confidence interval 2.3 to 4.1, P16 24 26 Three studies in high risk populations could not be included in the meta analysis, two because white matter hyperintensities were studied continuously only,23 25 and a third because only intracerebral haemorrhage was studied as an outcome (see web extra table 1).22 All three found a significant association of white matter hyperintensities with incident stroke.The meta analysis combining the data from population based and high risk populations yielded a significant association of white matter hyperintensities with incident stroke (3.5, 2.5 to 4.9, PIncident stroke typesFew data existed on the association of white matter hyperintensities with specific stroke types (intracerebral haemorrhage, ischaemic stroke). One community based study21 found a significant association of white matter hyperintensities with incident ischaemic stroke; another study did not observe any association of white matter hyperintensities with recurrent intracerebral haemorrhage in patients with lobar haemorrhage (see web extra high Quality Replica bags table 1).22Progression of white matter hyperintensities and incident strokeOnly one study assessed the relation between progression of white matter hyperintensities and incident stroke, in 89 patients with a history of lacunar stroke, headache, or dizziness: a significantly increased risk of stroke was observed in patients with progression of white matter hyperintensities after 4.3 years compared with those with no progression.16White matter hyperintensities and incident dementiaIncident dementia overallThree population based studies29 31 32 and 11 studies in high risk populations17 34 35 36 37 38 39 40 41 47 48 examined the relation between white matter hyperintensities and incident dementia overall (see web extra table 2). Meta analysing the three population based studies yielded a significant association of white matter hyperintensities with the occurrence of all types of dementia (2.9, 1.3 to 6.3, P=0.008; fig 3).29 31 32 Six of the 11 studies done in high risk populations could be included in the meta analysis,17 37 39 41 47 48 yielding no significant association of white matter hyperintensities with incident dementia (1.4, 0.9 to 2.3, P=0.14). Replica Handbags

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